It seems the combination of the changes and ticked checkbox means that when you click Edit, instead of displaying the date/time that the post was originally created it now displays the time when you hit Edit (even if you then untick the checkbox, it won't revert to the original date/time). And when you finish your edits and publish, you'll find that it's published as a brand new post, it doesn't publish back to its original location.
As Improbulus notes, since Blogger establishes post location / permalink based on time of publication, this is a problem. Solutions that are recommended there? Edit your posts in a browser that isn't running greasemonkey, or manually note the date & time from posts that you edit, and reset them to that time when you're ready to publish them again. Note that you can always alter date & time manually when you select the new "post & comment options" link at the bottom of the create post frame in the compose window.
Filed in: greasemonkey, blogger-hacks, firefox, blogger, blogtech